First-half strikes from Leonardo Spinazzola and Amir Rrahmani secured a two-goal victory for the visitors at the Stadio Olimpico in a match marred by a trio of red cards.
This result moves Napoli to just one point behind of Serie A pace-setters Milan, who prevailed on Friday. Inter occupy third place but have a chance to go back to the summit with a win in their later fixture.
Hampered by the absence of several key personnel, Napoli commanded the game with patient build-up play. The first goal arrived when Politano's delivery was volleyed home by Spinazzola at the back post.
The lead was extended in the first half as Rrahmani powered a header from another Politano free-kick into the net. Napoli came close to a third goal shortly after when Eljif Elmas watched his header crash against the woodwork.
After the break brought further worry for the away side when a winger was forced off. The stoppage sparked a brief altercation, resulting in yellow cards for a Napoli defender and Lazio's Tijjani Noslin—who then received a second caution for a challenge.
"My compliments to the lads, playing with this level of quality and intensity without letting the opposition have control is difficult," stated the winning manager. "We played at a exceptional level of quality."
Tempers flared again near the end as players from both sides became involved in a heated confrontation, prompting the coach to step in. The two players were dismissed for their part in the incident.
Over in La Liga, the Andalusian side endured a heavy loss at home to struggling Levante. Levante took control with a fine team goal before scoring two further strikes in the second half to seal a convincing victory.
Meanwhile, Los Blancos face major must-win when they play Betis, after their arch-rivals increased their advantage at the top. Later on other match, Atleti travel to face Real Sociedad.
Turning to Ligue 1, a historic capital derby takes place as the newly-promoted side visit powerhouses PSG. The fixture marks the inaugural top-flight meeting between the two clubs in decades, adding significant intrigue to the occasion.
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